The École Polytechnique Fédérale de Lausanne (EPFL) is one of the top European Universities participating in numerous national and international research projects. The Real-Time Coordination and Distributed Interaction Systems Group (React) belongs to the EPFL School of Engineering and carries out research in Distributed Systems, Technology Enhanced Learning (TEL) and Knowledge Management (KM). The group focuses on real-time and ubiquitous human-machine interaction, artifact-based collaborative learning, context-sensitive awareness and recommendation, smart devices, in addition to knowledge and resource management. React pioneered research and deployment of remote and virtual experimentation back to 1996 with a full remotely accessible lab for higher engineering education accessible 24/7 since 2001. Joint research on remote labs were carried out at the Swiss level in the eMersion project and at the European level with the RELAX project, a Remote LAboratory eXperimentation trial and in the AutoTECH project focusing on Automation Technicians Vocational Training Repository, as well as with dedicated work package in the ProLEARN network of Excellence. React had then a leading role in the Palette Integrated Project that aimed at facilitating and augmenting individual and organizational learning in Communities of Practice. In this framework, it investigated and developed social software to support formal and informal collaborative learning and ubiquitous knowledge sharing. In Go-Lab, EPFL ensures the technical coordination and well as the WP5 (Go-Lab Portal) leadership. There is a strong involvement in WP4 (Go-Lab Infrastructure) and ensure the communication between WP3 (Participatory design) and the technical work packages. EPFL is finally involved in WP9 (Dissemination and Exploitation) as member of standardization bodies.